Published December 2007 | Version v1
Journal article Metadata-only

Drug release assays from new chitosan/pHEMA membranes obtained by gamma irradiation

Creators

  • 1. Department of Physics, Nuclear and Technological Institute, E.N. 10, 2686-953 Sacavem (Portugal)
  • 2. Department of Chemical Engineering, Faculty of Science and Technology, University of Coimbra, Polo II Pinhal de Marrocos, 3030-290 Coimbra (Portugal)
  • 3. Chemistry and Biochemistry Centre and Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisboa, 1749-016 Lisbon (Portugal)
  • 4. Department of Chemistry, Nuclear and Technological Institute, E.N. 10, 2686-953 Sacavem (Portugal)

Description

With the purpose of obtaining a biocompatible and microbiologically safe matrix that simultaneously could be used as wound dressing material and as a controlled drug release system, membranes with different thickness and different contents in chitosan and hydroxyethyl methacrylate (HEMA) have been prepared by γ irradiation from a 60Co source. Antibiotic release experiments were performed before or after irradiation over amoxicillin loaded chitosan/pHEMA membranes in physiological saline solution, and monitored by UV-Vis spectrometry. Results point out a fast amoxicillin release with similar release profile in all studied membranes. The amount of released drug was shown to be dependent on membranes network crosslinking due composition, radiation and membrane thickness

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nimb.2007.09.013

Additional details

Identifiers

DOI
10.1016/j.nimb.2007.09.013;
PII
S0168-583X(07)01461-9;

Publishing Information

Journal Title
Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
Journal Volume
265
Journal Issue
1
Journal Page Range
p. 406-409
ISSN
0168-583X
CODEN
NIMBEU

Conference

Title
7. international symposium on ionizing radiation and polymers
Dates
23-28 Sep 2006
Place
Antalya (Turkey)

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
39051582
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AMINO ACIDS; ANTIBIOTICS; COBALT 60; CROSS-LINKING; GAMMA RADIATION; IRRADIATION; MEMBRANES; METHACRYLATES; OLIGOSACCHARIDES; SOLUTIONS; SPECTROSCOPY; THICKNESS; WOUNDS
Descriptors DEC
ANTI-INFECTIVE AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; CARBOXYLIC ACID SALTS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; COBALT ISOTOPES; DIMENSIONS; DISEASES; DISPERSIONS; DRUGS; ELECTROMAGNETIC RADIATION; HOMOGENEOUS MIXTURES; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; MIXTURES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; POLYMERIZATION; RADIATIONS; RADIOISOTOPES; SACCHARIDES; YEARS LIVING RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.