Published October 2011 | Version v1
Journal article Metadata-only

Interest of positron emission tomography with [18F]-fluoro-misonidazole within the frame of a dose escalation for glioblastomas

Creators

  • 1. Service de radiotherapie, CHU de Bordeaux, Bordeaux (France)
  • 2. Service de medecine nucleaire, CHU de Bordeaux, Bordeaux (France)
  • 3. Service de neurochirurgie, CHU de Bordeaux, Bordeaux (France)

Description

Eleven patients suffering from an unresectable glioblastoma have been treated by positron emission tomography (PET) with [18F]-FMiso and submitted to a MRI before treatment. Gross target volumes (GTV) have been determined, as well as hypoxic fraction within the tumours. A complication probability calculation has been performed. It appears that the PET-[18F]-FMiso allows a smaller volume than MRI to be defined. A Normal Tissue Complication Probability (NTCP) modelling shows that this volume limits the complication risk increase due to dose escalation. Intensity modulation allows a better taking into account of these potential benefits of this biological target volume definition. Short communication

Availability note (English)

Available from doi: http://dx.doi.org/10.1016/j.canrad.2011.07.152

Additional details

Additional titles

Original title (French)
Interet de la tomographie par emission de positrons au [

Identifiers

DOI
10.1016/j.canrad.2011.07.152;

Publishing Information

Journal Title
Cancer Radiotherapie
Journal Volume
15
Journal Issue
6-7
Journal Page Range
p. 614-615
ISSN
1278-3218
CODEN
CARAFC

Conference

Title
22. national congress of the French society of oncological radiotherapy (SFRO)
Original Conference Title
22. congres national de la Societe Francaise de Radiotherapie Oncologique (SFRO)
Dates
5-7 Oct 2011
Place
Paris (France)

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
43041614
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AUGMENTATION; DOSE-RESPONSE RELATIONSHIPS; EFFICIENCY; GLIOMAS; MISONIDAZOLE; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIOTHERAPY; RISK ASSESSMENT
Descriptors DEC
ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; NITRO COMPOUNDS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOLOGY; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; THERAPY; TOMOGRAPHY