Published August 1985
| Version v1
Journal article
Synthesis of 2-n butyl 3-(3,5-125diiodo 4-(N,N-diethylamino 2-ethoxybenzoyl)) benzofuran hydrochloride (125I amiodarone)
Description
125I Amiodarone an antianginal and antiarrhythmic agent, was prepared by iodination of 2-n butyl 4-hydroxy 3-benzoyl benzofuran with Na125I in alkaline medium. By amination with N,N-diethyl 2-amino 1-chloroethane, 125I amiodarone was obtained with 30% yield and a specific activity of about 1 Ci/mmol. (author)
Additional details
Publishing Information
- Journal Title
- J. Labelled Compd. Radiopharm.
- Journal Volume
- 22
- Journal Issue
- 8
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 799-806
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 17018691
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- BENZOFURANS; CARDIOVASCULAR AGENTS; CHEMICAL PREPARATION; IODINE 125; LABELLING; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; FURANS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS