Published 1993 | Version v1
Report Metadata-only

Mutation studies upon spermatogonial stem cells of mammals and genetic tests for non-disjunction in the mouse

Creators

  • 1. Hammersmith Hospital, London (United Kingdom). MRC Radiobiological Unit

Description

Studies upon strain differences in genetic response to radiation may facilitate extrapolation of mouse data to man. The objective of the project is to investigate the basis of the genetic responses obtained with different treatment regimes. Two systems of genetic (complementation) tests were developed using Robertsonian translocations in tester animals to detect non-disjunction and chromosome loss events in normal mice. The aim is to evaluate the two methods for detecting chromosome 11 loss, and compare the frequency of chromosomes 11 and 13 loss following X-irradiation of males and females. (R.P.) 6 refs., 3 tabs

Part of:
Rdiation protection. Progress report 1990-91

Additional details

Publishing Information

Imprint Title
Rdiation protection. Progress report 1990-91
Imprint Pagination
1571 p.
Journal Page Range
p. 868-872.
Report number
EUR--14927

INIS

Country of Publication
European Commission (EC), Brussels (Belgium)
Country of Input or Organization
European Commission (EC), Brussels (Belgium)
INIS RN
25055071
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S99: GENERAL AND MISCELLANEOUS;
Resource subtype / Literary indicator
Progress Report
Descriptors DEI
GENETIC RADIATION EFFECTS; MAN; MICE; MUTATIONS; PROGRESS REPORT; RADIATION DOSES; SPERMATOGONIA; STEM CELLS; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DOCUMENT TYPES; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; GERM CELLS; IONIZING RADIATIONS; MAMMALS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES

Optional Information

Contract/Grant/Project number
Contract Bi6-143
Notes
Imprint:Also published in DE, FR.