Published February 4, 1985
| Version v1
Journal article
Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients
Creators
- 1. MRC Clinical Research Centre, Harwood, England
Description
Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. 125 I-BH CCK33 specific binding was reduced by 40% (p < 0.02) in the hippocampus and by 20% (p < 0.01) in the frontal cortex of schizophrenic patients compared with controls. There were no differences in 125I-BH CCK33 binding between the two groups in the amygdala, temporal cortex or caudate nucleus. 20 references, 1 figure, 2 tables
Additional details
Publishing Information
- Journal Title
- Life Sci.
- Journal Volume
- 36
- Journal Issue
- 5
- Series
- Life Sci.
- Journal Page Range
- 473-477
- ISSN
- 0024-3205
- CODEN
- LIFSA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17009447
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- AFFINITY; AUTOPSY; BRAIN; CELL MEMBRANES; CHEMICAL BONDS; IODINE 125; LABELLED COMPOUNDS; MENTAL DISORDERS; PATIENTS; POLYPEPTIDES; TRACER TECHNIQUES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BODY; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEMBRANES; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDES; PROTEINS; RADIOISOTOPES