Published January 2012 | Version v1
Journal article Metadata-only

Ginkgo biloba extract alters the binding of the sodium [123I] iodide (Na123I) on blood constituents

Creators

  • 1. Comissão Nacional de Energia Nuclear, Instituto de Engenharia Nuclear, Cidade Universitária, Ilha do Fundão, Via Cinco s/n, 21945–450 Rio de Janeiro (Brazil)
  • 2. Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcântara Gomes, Departamento de Biofísica e Biometria, 28 de Setembro, 87, 20551-030, Rio de Janeiro, RJ (Brazil)
  • 3. Programa de Pós-Graduação em Ciências Médicas, Universidade Federal Fluminense, 24030-210, Niterói, RJ (Brazil)
  • 4. Departamento de Patologia, Universidade Federal Fluminense, 24030-210, Niterói, RJ (Brazil)

Description

We evaluated the in vitro effect of an aqueous extract of Ginkgo biloba (EGb) on the distribution in blood cells (BC) and plasma (P) and on the binding of Na123I to the blood constituents using precipitation with trichloroacetic acid. The radioactivity percentages insoluble (SF) and insoluble fraction (IF) of blood constituents were determined. The EGb interfered (p<0.05) on the distribution of Na123I in the P (from 69.64 to 86.13) and BC (from 30.36 to 13.87) and altered the fixation of the Na123I in IF-P and in IF-BC. - Highlights: ► Interaction between the Ginkgo biloba and blood constituents radiolabeled. ► Modification of the binding of sodium iodide (Na123I) to the blood constituents. ► This alteration should have influence in a diagnosis of nuclear medicine.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2011.08.002

Additional details

Identifiers

DOI
10.1016/j.apradiso.2011.08.002;
PII
S0969-8043(11)00407-6;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
70
Journal Issue
1
Journal Page Range
p. 59-62
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
43072868
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
BLOOD CELLS; CARBOXYLIC ACIDS; DIAGNOSIS; IN VITRO; IODINE 123; MODIFICATIONS; PLASMA; PRECIPITATION; RADIOPHARMACEUTICALS; SODIUM IODIDES
Descriptors DEC
ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; INORGANIC PHOSPHORS; INTERMEDIATE MASS NUCLEI; IODIDES; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PHOSPHORS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; SODIUM COMPOUNDS

Optional Information

Copyright
Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.