Published 1993 | Version v1
Miscellaneous Metadata-only

Studies concerning the interaction between local anesthetics and lipid membrane by phosphorus-31, deuterium and proton NMR

Creators

  • 1. Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Dept. de Bioquimica
  • 2. National Research Council of Canada, Ottawa, ON (Canada). Inst. for Biological Sciences
  • 3. Sao Paulo Univ., SP (Brazil). Inst. de Quimica

Description

Local anesthetics block the conduction of nervous stimulus by impeding the entrance of sodium ion and the consequently depolarization of the nervous membrane. The action mechanism of local anesthetics, however, is not fully understood yet. In the present work the interaction between local anesthetics and membranes are studied by the perspective of lipid phase perturbation using NMR to elucidate the mechanism. Results are presented and discussed

Part of:
Carbon-13 NMR of some aliphatic ketones

Additional details

Additional titles

Original title (Portuguese)
Estudo da interacao entre anestesicos locais e membranas lipidicas por ressonancia magnetica de fosforo (

Publishing Information

Imprint Title
Proceedings of the 4. Meeting of the nuclear magnetic resonance users
Imprint Pagination
465 p.
Journal Page Range
p. 461-465

Conference

Title
4. meeting of the nuclear magnetic resonance users
Original Conference Title
4. Encontro de usuarios de ressonancia magnetica nuclear
Dates
11-15 May 1993
Place
Angra dos Reis, RJ (Brazil)

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
29044659
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
ANESTHETICS; DEUTERIUM; DIAGNOSTIC USES; LIPIDS; NUCLEAR MAGNETIC RESONANCE; ORGANIC COMPOUNDS; PARTITION; PHOSPHORUS 31; PROTONS; SOLUBILITY
Descriptors DEC
BARYONS; CATIONS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHARGED PARTICLES; DRUGS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HYDROGEN IONS; HYDROGEN IONS 1 PLUS; HYDROGEN ISOTOPES; IONS; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; NUCLEI; NUCLEONS; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHOSPHORUS ISOTOPES; RESONANCE; STABLE ISOTOPES; USES

Optional Information

Notes
5 refs., 1 fig., 1 tab. Imprint:Anais do 4. Encontro de usuarios de ressonancia magnetica nuclear