Published January 1986
| Version v1
Journal article
Effect of irradiation on ethyl nitrosourea induced neural tumours in Wistar rat
Description
Wistar rats received 2 Gy whole body irradiation followed immediately by 10 mg/kg of ethyl nitrosourea (ENU) on the day of birth. Out of 33 rats which were given ENU alone 14 developed 22 tumors of the nervous system, out of which 15 (68,2%) were gliomas and 7 (31.8%) were Schwannomas. Out of 34 rats which were given both irradiation and ENU 12 were found to harbour 15 neural tumors out of which 14 (93.3%) were gliomas and 1 (7.1%) was a Schwannoma. The pretreatment with irradiation seems to have resulted in selective suppression of Schwannoma induction. (author)
Additional details
Publishing Information
- Journal Title
- Cancer Lett.
- Journal Volume
- 30
- Journal Issue
- 1
- Series
- Cancer Lett.
- Journal Page Range
- 85-90
- ISSN
- 0304-3835
- CODEN
- CALED
INIS
- Country of Publication
- Ireland
- Country of Input or Organization
- Ireland
- INIS RN
- 17031532
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CARCINOGENESIS; COBALT 60; FETUSES; MORTALITY; NEONATES; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NITROSO COMPOUNDS; PREGNANCY; RATS; UREA; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBONIC ACID DERIVATIVES; COBALT ISOTOPES; DISEASES; EXTERNAL IRRADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOGENESIS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 11 refs.