Extraction of thallium-201 by the myocardium
Description
The concentration of thallium-201 in the myocardium immediately following injection of tracer is the result of both blood flow delivering tracer to the heart and extraction by the myocardium. In these studies, the extraction of thallium-201 by the canine myocardium was determined as a function of heart rate, coronary blood flow, hypoxia, changes in pH, and following administration of propranolol, insulin, and strophanthin. Under basal conditions, extraction fraction measured 88 +- 2.1%, following pacing to a rate of 195 beats/min extraction fraction remained unchanged at 88.5%. Similar results were found with changes in pH, propranolol, insulin, and strophanthin. Hypoxia caused a significant decrease in extraction fraction to 77.9%. When coronary blood flow was increased in excess of demands by drugs, extraction fraction fell logarithmically
Additional details
Identifiers
Publishing Information
- Journal Title
- Circulation
- Journal Volume
- 56
- Journal Issue
- 2
- Series
- Circulation.
- Journal Page Range
- 188-191
- ISSN
- 0009-7322
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 8346959
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANOXIA; BLOOD FLOW; INSULIN; MYOCARDIUM; PH VALUE; RADIONUCLIDE KINETICS; SEPARATION PROCESSES; STROPHANTIN; THALLIUM 201
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLYCOSIDES; HEART; HEAVY NUCLEI; HORMONES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; STEROIDS; THALLIUM ISOTOPES
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent