Published January 1, 2011 | Version v1
Journal article Metadata-only

Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography

Creators

  • 1. MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, Guangdong Province (China)
  • 2. Department of Anesthesiology, the Second Affiliated Clinical Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province (China)
  • 3. Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian (China)
  • 4. Department of Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province (China)
  • 5. Laser Medicine Lab, Department of Biomedical Engineering, School of Pre-Clinical Medicine of Sun Yet-Sen University, Guangzhou Guangdong 510080 (China)

Description

We report our pilot results on quantification of glucose (G) diffusion permeability in human normal esophagus and ESCC tissues in vitro by using OCT technique. The permeability coefficient of 40% aqueous solution of G was found to be (1.74±0.04)×10-5 cm/s in normal esophagus and (2.45±0.06)×10-5 cm/s in ESCC tissues. The results from this study indicate that ESCC tissues had a higher permeability coefficient compared to normal esophageal tissues, and the light penetration depths gradually increase with the increase of applied topically with G time for the normal esophageal and ESCC tissues. The results indicate that the permeability coefficient of G in cancer tissues was 1.41-fold than that in normal tissues, and the light penetration depth for the ESCC tissues is significantly smaller than that of normal esophagus tissues in the same time range. These results demonstrate that the optical clearing of normal and cancer esophagus tissues are improved after application of G

Availability note (English)

Available from http://dx.doi.org/10.1002/lapl.201010081

Additional details

Identifiers

DOI
10.1002/lapl.201010081;

Publishing Information

Journal Title
Laser physics letters (Internet)
Journal Volume
8
Journal Issue
1
Journal Page Range
p. 71-77
ISSN
1612-202X

INIS

Country of Publication
Russian Federation
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46020069
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANIMAL TISSUES; AQUEOUS SOLUTIONS; COMPARATIVE EVALUATIONS; DIFFUSION; ESOPHAGUS; GLUCOSE; HUMAN POPULATIONS; NEOPLASMS; OPTICS; PENETRATION DEPTH; PERMEABILITY; TOMOGRAPHY; VISIBLE RADIATION
Descriptors DEC
ALDEHYDES; BODY; CARBOHYDRATES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; ELECTROMAGNETIC RADIATION; EVALUATION; HEXOSES; HOMOGENEOUS MIXTURES; MIXTURES; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PHYSICAL PROPERTIES; POPULATIONS; RADIATIONS; SACCHARIDES; SOLUTIONS