Bronchography by tantalum aerosols, an experimental investigation of lung clearance and retention
Description
Lung clearance of tantalum used as contrast medium has been studied in three animal species: rat, monkey and cat. In rats and monkeys, 80 to 90 percent of the inhaled tantalum was removed with a half life of 10 to 30 hr, but the residual fraction was removed with a half life longer than 100 days; consequently persistent roentgenographic pictures could be observed. These results were in accordance with those obtained by other authors studying dogs and men (accidental inhalation of radioactive tantalum). In cats, about 98 percent was removed with a half life of 15 hr and the remaining fraction with a half life of 18 days. In the three species, the physiological lung clearance mechanisms did not seem disturbed. Microscopic examination showed the peribronchiolar localisation of remaining tantalum in rats and monkeys, with proliferation of granulomes and fibrotic reaction. These results must induce to the greatest care when using tantalum in man in order to outline peripheral airways
Availability note (English)
MF available from INIS under the Report Number.Abstract (French)
On a etudie la vitesse d'elimination du tantale utilise comme opacifiant de l'arbre bronchique, sur trois especes animales: rat, singe et chat. Pour le rat et le singe, 80 a 90% de la quantite d'opacifiant insufflee s'epure avec une periode de 10 a 30 heures, mais la fraction residuelle ne s'epure qu'avec une periode superieure a 100 jours, entrainant la persistance d'images radiographiques. Ces resultats confirment ceux obtenus par d'autres auteurs sur le chien et sur l'homme (inhalation accidentelle de tantale radioactif). Pour le chat, environ 98% s'epurent avec une periode de 15 heures et le reste avec une periode de 18 jours. Chez les trois especes, la fonction d'auto-epuration du poumon ne semble pas perturbee. Des examens anatomo-pathologiques ont montre la localisation peribronchiolaire du tantale residuel chez le rat et le singe, avec developpement de granulomes et de reactions fibrotiques. Ces resultats conduisent a emettre les plus grandes reserves quant a l'utilisation, chez l'homme, du tantale comme opacifiant des bronches distalesFiles
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Additional details
Additional titles
- Original title (French)
- La bronchographie par insufflation de poussieres de tantale. Etude experimentale de l'equation pulmoniare. Retention parenchymateuse de l'opacifiant
Publishing Information
- Imprint Pagination
- 108 p.
- Report number
- CEA-R--4680
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 7233440
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- BIOMEDICAL RADIOGRAPHY; BRONCHI; CATS; INHALATION; LUNG CLEARANCE; LUNGS; MACACUS; PATHOLOGICAL CHANGES; RADIONUCLIDE ADMINISTRATION; RADIONUCLIDE KINETICS; RATS; RESPIRATORS; RETENTION; RETENTION FUNCTIONS; TANTALUM; TANTALUM 182; TOXICITY
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EXCRETION; HEAVY NUCLEI; INTAKE; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MEDICINE; METALS; MINUTES LIVING RADIOISOTOPES; MONKEYS; NUCLEI; ODD-ODD NUCLEI; ORGANS; PRIMATES; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; TANTALUM ISOTOPES; TRANSITION ELEMENTS; VERTEBRATES