Published December 21, 1987 | Version v1
Journal article Metadata-only

Bone marrow cells homing to the thymus in mice after a leukemogenic split dose irradiation

Creators

  • 1. Liege Univ. (Belgium). Lab. d'Anatomie Pathologique

Description

Fractionated whole body X-irradiation (4 x 1.75 Gy at weekly intervals) induces a high percentage of thymic lymphomas in C57Bl/Ka mice. These tumors develop after a long latency period during which the thymic lymphopoiesis is deeply altered. In the present work, we test wether those modifications are due to a lack of prothymocyte homing to preleukemic thymuses. Our results show that the preleukemic state of the thymus don't prevent the homing of normal marrow precursors grafted immediately after an irradiation of 4 Gy. Thus the alterations of thymic lymphopoiesis observed after a leukemogenic irradiation are not due to a modification in the thymus receptivity to thymocyte precursors

Abstract (French)

Chez la Souris C57Bl/Ka, une irradiation fractionnee corporelle totale (4 x 1,75 Gy appliques a une semaine d'intervalle) induit la formation de lymphomes thymiques; ces tumeurs se developpent apres une longue periode de latence durant laquelle on observe des troubles de la lymphopoiese thymique. Dans ce travail, nous avons recherche si ces perturbations sont dues a des troubles de la migration des prothymocytes vers les thymus preleucemiques. Nos resultats indiquent que l'etat preleucemique des thymus n'empeche pas la migration des precurseurs thymocytaires provenant d'une moelle normale greffee directement apres une irradiation de 4 Gy. Les troubles de la lymphopoiese thymique observes apres une irradiation leucemogene ne sont donc pas dus a une modification de la receptivite des thymus vis-a-vis des precurseurs thymocytaires

Additional details

Additional titles

Original title (French)
Migration des cellules medullaires vers le thymus chez les souris C

Publishing Information

Journal Title
C. R. Seances Soc. Biol. Fil.
Journal Volume
181
Journal Issue
4
Series
C. R. Seances Soc. Biol. Fil.
Journal Page Range
426-431
ISSN
0037-9026
CODEN
CRSBA

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
19044640
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BONE MARROW CELLS; FRACTIONATED IRRADIATION; LATENCY PERIOD; LEUKEMOGENESIS; LEUKOPOIESIS; LYMPHOMAS; MICE; THYMOCYTES; THYMUS; WHOLE-BODY IRRADIATION; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BLOOD FORMATION; BODY; CARCINOGENESIS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; NEOPLASMS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES