Effects of some nonradioactive and radioactive chemical compounds on the spleen structure

Mouse and rat spleens were investigated in dynamics by the morphometry and electron microscopy methods; for 1-2 years mice and rats were receiving 137Cs, 226Ra, 89Sr, 65Zn, Pb(NO3)2, BeCI2 etc., added into potable water. It is established, that reactive rebuilding under both chemical and radiation effects occurs in three directions: lymphoid tissue hyperplasia, plasmocytogenesis amplification as well as hyperplasia of extramedullary blood formation. At strong total received doses (160-200 rad) atrophy, amyloid spleen degeneration or leucosis symptoms were observed in 1-2 years. Disturbance of intercellular contacts and intracellular regeneration processes has been determined by the electron microscopy