Published February 2016 | Version v1
Journal article Metadata-only

Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats

Creators

  • 1. Payame Noor University, Tehran (Iran, Islamic Republic of). Department of Biology
  • 2. Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of). Radiation Application Research School
  • 3. Babol University of Medical Sciences, Babol (Iran, Islamic Republic of). Department of Nuclear Medicine, Shahid Beheshti Hospital
  • 4. Micromod Partikeltechnologie GmbH, Rostock (Germany)
  • 5. Tehran University of Medical Science, Tehran (Iran, Islamic Republic of). Department of Medical Physics and Biomedical Engineering, Faculty of Medicine

Description

Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho-DTPA-SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15 % of injected dose was in liver and spleen at 30 min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
307
Journal Issue
2
Journal Page Range
p. 1559-1566
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
47015357
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
CLEARANCE; CROSS-LINKING; DEXTRAN; DTPA; HOLMIUM 166; INTRAVENOUS INJECTION; IRON OXIDES; LABELLING; LIVER; MAGNETIC MATERIALS; MAGNETIC RESONANCE; NANOPARTICLES; RATS; RETICULOENDOTHELIAL SYSTEM; SPLEEN; SYNTHESIS; TISSUE DISTRIBUTION; TRACER TECHNIQUES
Descriptors DEC
AMINO ACIDS; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD SUBSTITUTES; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; CHALCOGENIDES; CHELATING AGENTS; CHEMICAL REACTIONS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISTRIBUTION; DRUGS; GLANDS; HEMATOLOGIC AGENTS; HOLMIUM ISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IRON COMPOUNDS; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PARTICLES; POLYMERIZATION; POLYSACCHARIDES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH NUCLEI; RESONANCE; RESPONSE MODIFYING FACTORS; RODENTS; SACCHARIDES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
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