Published August 1982 | Version v1
Journal article Metadata-only

The effect of UV irradiation on proliferation and life span of human diploid fibroblast-like cells

Creators

  • 1. Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma

Description

The effect of low dose UV irradiation on the reinitiation of proliferative activity and on the life span of human diploid fibroblast-like cells is described. Cells were exposed to UV at confluence or after maintenance in an arrested state. Cell division was stimulated immediately after UV irradiation or after an additional post-UV incubation period. Arrested populations of all in vitro ages exhibited a greater sensitivity to UV and the reinitiation of proliferation was enhanced by post-UV incubation before stimulation. Ultraviolet light had no effect on life span regardless of in vitro cell age, culture state at the time of exposure, or the presence of a postirradiation period of arrest

Additional details

Publishing Information

Journal Title
In Vitro
Journal Volume
18
Journal Issue
8
Series
In Vitro.
Journal Page Range
703-707
ISSN
0073-5655

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
14754623
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; CELL PROLIFERATION; DIPLOIDY; FIBROBLASTS; LIFE SPAN; LOW DOSE IRRADIATION; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IRRADIATION; PLOIDY; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS