The efficacy of 99Tcm-MIBI myocardial perfusion imaging in detecting myocardial ischemia in patients with kawasaki disease

Objective: 99Tcm-methoxyisobutylisonitrile (MIBI) myocardial perfusion imaging was undertaken to detect myocardial ischemia in children with Kawasaki disease in order to evaluate its diagnostic value. Methods: Thirty-one children with Kawasaki disease were included. Five children without cardiovascular disease were enrolled as control group. of these 31 study subjects, there were classified into three groups according to their clinical manifestations. There were acute phase (n=15), sub-acute phase (n=9), and chronic phase (n=7). 99Tcm-MIBI myocardial perfusion SPECT imaging was proformed in all patients. Eight patients with positive result repeated their SPECT imaging during 6-12 months after their first scan. Results: Thirteen of 31 (41.9%) patients were positive in MIBI perfusion imaging. Six (6/15) were at acute phase, 4 (4/9) were at sub-acute phase, and 3 (3/7) were at chronic phase. Of the 8 patients had second MIBI scans, 4 were normal, 3 improved significantly, only 1 unchanged. Conclusion: 99Tcm-MIBI myocardial perfusion imasins is a useful noninvasive method for diagnosis evaluation of myocardial ischemia in Kawasaki disease. (authors)