Published 1990 | Version v1
Journal article Metadata-only

'Home made' - preparation and biological distribution of 99mTc-MAG3

Creators

  • 1. Staedtisches Klinikum, Berlin-Buch (German Democratic Republic). Nuklearmedizinische Klinik

Description

Bz-MAG3 was synthetized in a known manner and characterized using ultimate analysis, H-NMR, IR and electron impingement mass spectroscopy. The labelling using the stannous chloride method and tartrate as auxiliary ligand yielded 99mTc-MAG3 with an average radiochemical purity of 96.4% and sufficient stability. The correct organ distribution and blood clearance in comparison with a reference preparation is proved by animal experiments. With an acceptable expenditure a technique has been developed to make the very expensive 99mTc-MAG3 more cheaply available. (author)

Additional details

Additional titles

Original title (German)
'Home made' - Praeparation und biologische Pruefung von

Publishing Information

Journal Title
Medicina Nuclearis
Journal Volume
2
Journal Issue
2
Series
Med. Nucl.
Journal Page Range
124-132
ISSN
0863-1271
CODEN
MEDNU

INIS

Country of Publication
Germany
Country of Input or Organization
German Democratic Republic
INIS RN
21078148
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CHEMICAL PREPARATION; EXCRETION; HIPPURAN; INFRARED SPECTRA; IODINE 131; LABELLING; MASS SPECTROSCOPY; MICE; NMR SPECTRA; QUANTITATIVE CHEMICAL ANALYSIS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; TECHNETIUM COMPLEXES; TECHNETIUM 99; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; CLEARANCE; COMPLEXES; CONTRAST MEDIA; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SPECTRA; SPECTROSCOPY; SYNTHESIS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES