Published April 1996 | Version v1
Journal article Metadata-only

Studies on the synthesis of 16α-[18F]fluoroestradiol

Creators

  • 1. Forschungszentrum Rossendorf e.V. (FZR) (Germany). Inst. fuer Bioanorganische und Radiopharmazeutische Chemie
  • 2. Hans-Knoell-Institut, Jena (Germany)

Description

For preparing 16α-[18F]fluoroestradiol, a new one-pot procedure reported in the literature was elaborated in detail. The experimental conditions for synthesizing the required precursor and for converting it into 16α-fluoroestradiol or 16α-[18F]fluoroestradiol are given. The synthesis consists of the fluoridation reaction and hydrolysis reactions. For rapid hydrolysis of the fluorosteroid formed in the fluoridation reaction two methods are presented. The synthesis time does not exceed 1 h. Pure 16α-[18F]fluoroestradiol can be obtained in a 70% overall radiochemical yield. (Author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
47
Journal Issue
4
Journal Page Range
p. 395-399.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
27058962
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; ESTRADIOL; FLUORINATION; FLUORINE 18; HYDROLYSIS; LABELLING; ORGANIC FLUORINE COMPOUNDS; RADIOPHARMACEUTICALS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; ESTRANES; ESTROGENS; FLUORINE ISOTOPES; HALOGENATION; HORMONES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SOLVOLYSIS; STEROID HORMONES; STEROIDS; SYNTHESIS; YIELDS