Published 1974
| Version v1
Book
Differences between peripheral and portal injection of 125I-insulin in the evaluation of insulin kinetics in the dog
Creators
- 1. Pisa Univ. (Italy). Istituto di Patologia Speciale Medica e Metodologia Clinica
- 2. Consiglio Nazionale delle Ricerche, Pisa (Italy). Lab. di Fisiologia Clinica
Description
In kinetic studies, the peripheral injection of the tracer brings about a systematic error which equally affects MCR and secretion rate, this latter being the product of the clearance by the plasma concentration of the native hormone. Such an error is due to the first-passage hepatic extraction. From our experiments, in dog this extraction is about 20%. Several studies, conducted by the isolated organ perfusion technique, report a first-passage hepatic extraction ranging from 60 to 40% for cold insulin, and from 40 to 3% for labelled insulin. These differences can be accounted for by different experimental conditions, the quality of the tracer and the system of detecting the radioactive hormone in plasma. (orig.)
Abstract (German)
In kinetischen Untersuchungen bringt die periphere Injektion des Indikators einen systematischen Fehler mit sich, der sowohl die MCR (metabolic clearance rate) als auch die Sekretionsrate beeinflusst, da die letztere das Produkt aus der Clearance und der Plasmakonzentration des Nativhormons darstellt. Dieser Fehler beruht auf der Leberextraktion bei der ersten Passage. Nach unseren Experimenten liegt diese Extraktion beim Hund bei etwa 20%. Verschiedene Untersuchungen nach der Methode der isolierten Organperfusion berichten ueber eine Leberextraktion bei der ersten Passage, die bei kaltem Insulin etwa 60-40% und bei markiertem Insulin 40-3% betraegt. Diese Unterschiede lassen sich durch unterschiedliche Versuchsbedingungen, die Qualitaet des verwendeten Indikators und das System zur Auffindung des radioaktiven Hormons im Plasma erklaeren. (orig./AK)Additional details
Additional titles
- Original title (no language)
- Nuklearmedizin.
Publishing Information
- Publisher
- Schattauer.
- Imprint Place
- Stuttgart, F.R. Germany
- ISBN
- 3794504593
- Imprint Title
- Nuclear medicine
- Imprint Pagination
- p. 405-410.
Conference
- Title
- 12. international annual meeting of the Gesellschaft fuer Nuclearmedizin e.V.
- Dates
- 11 Sep 1974.
- Place
- Muenchen, F.R. Germany.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 7251533
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- COMPARTMENTS; DISTRIBUTION; DOGS; EXTRACELLULAR SPACE; INSULIN; IODINE 125; MATHEMATICS; PANCREAS; RADIONUCLIDE KINETICS; RETENTION; RETENTION FUNCTIONS; TRACER TECHNIQUES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PEPTIDE HORMONES; RADIOISOTOPES; VERTEBRATES
Optional Information
- Notes
- 1 fig.; 1 tab.; 8 refs. Imprint:Nuklearmedizin.;Fortschritte der Nuklearmedizin in klinischer und technologischer Sicht.
- Secondary number(s)
- AED-Conf--74-544-021.