A study on pharmacokinetics of 3H-mitoxantrone in experimental animals
Creators
- 1. West China Univ. of Medical Sciences, Chendu (China). Dept. of Pharmacology
Description
Mitroxantrone (DHAQ) is a new semisynthetic antitumor drug prepared in China. This paper reports the pharmacokinetic studies of 3H-mitoxantrone in mice by liquid scintillation. The results showed that the decline of radioactivity in the plasma was a biphasic curve after intramuscular and intravenous injection in rats. The adsorption of 3H-DHAQ was ready and completed after intramuscular injection. It was widely distributed in body tissues. The concentration order of various organs was liver > intestine > kidney > lung > heart > muscles > brain. The elimination of the drug was slow, T1/2 was 42.56 h. In 72h after administration the cumulative excretion of radioactivity in urine was 7% of the total dose, while that in feces was 43%. The main forms of the drug in urine were its metabolites
Additional details
Publishing Information
- Journal Title
- Journal of West China University of Medical Sciences
- Journal Volume
- 21
- Journal Issue
- 4
- Series
- J. West China Univ. Med. Sci.
- Journal Page Range
- 406-409
- ISSN
- 0257-7712
- CODEN
- HYDXE
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 22084140
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; EXCRETION; LABELLED COMPOUNDS; METABOLISM; PHARMACOLOGY; TISSUE DISTRIBUTION; TRACER TECHNIQUES; TRITIUM; UPTAKE
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CLEARANCE; DISTRIBUTION; DRUGS; HYDROGEN ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES