Indium-113m-phytate liver scanning agent

The method of labelling sodium phytate by indium-113m is elaborated. Examination of radiochemical purity by thin-layer chromatography on Sephadex G-15 with ascending 15% Na-azide indicates that in the final product the content of labelled phytate complex was above 90% and the content of unbound indium was less than 5%. Biological investigations included determining the organ distribution, the liver, lung and spleen clearances, the wholebody retention and urine excretion of the radiopharmaceutical after IV injection in normal Swiss mice and Wistar rats. The biological study indicates a selective uptake of 113Insup(m)-phytate in liver - about 80% of the initial dose 15 min post administration. Clinical investigation of the usefulness of this labelled compound was performed on 120 patients with various liver diseases. The results showed that 113Insup(m)-phytate is very useful for liver imaging, especially for children and when examinations must be repeated several times. (author)