Published June 1985
| Version v1
Journal article
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer
- 1. George Washington Univ. Medical Center, Washington, DC
Description
3-Quinuclidinyl 4-iodobenzilate was shown to bind to the muscarinic acetylcholine receptor (mAChR) by testing the saturability and the stereoselectivity in the corpus striatum, cerebellum, and the heart. But the ratio of radioactivity in tissues containing different concentrations of mAChR was less than the ratio of mAChR concentrations determined by in vitro saturation assay. As a result, the sensitivity to change in receptor concentration by external imaging will be reduced for this receptor binding radiotracer
Additional details
Additional titles
- Augmented title (English)
- Rats
Publishing Information
- Journal Title
- J. Nucl. Med.
- Journal Volume
- 26
- Journal Issue
- 6
- Series
- J. Nucl. Med.
- Journal Page Range
- 637-642
- ISSN
- 0022-3123
- CODEN
- JNMEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17009408
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ACETYLCHOLINE; CEREBELLUM; CEREBRUM; DISTRIBUTION; HEART; HYDROXY ACIDS; IN VITRO; IODINE 125; ORGANIC IODINE COMPOUNDS; RATS; RECEPTORS; TISSUES; TRITIUM COMPOUNDS
- Descriptors DEC
- AMINES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ESTERS; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PARASYMPATHOMIMETICS; QUATERNARY COMPOUNDS; RADIOISOTOPES; RODENTS; VERTEBRATES