Comparative study of PVP hydrogel obtained by reaction of fenton and gamma radiation

Polyvinylpyrrolidone (PVP) is a polymeric matrix having the capacity to absorb great quantity of water without solving and, due to this property can be used as matrix to compose a pharmaceutical controlled liberation system. In these work, PVP hydrogels were prepared solving the polymer under different concentrations (8%, 10%, 15% and 20%) in phosphate tampon solutions, promoting the reticulation through two methods: by chemical reaction (Fenton reaction), and by ionizing radiation. The objective of this study was to compare the PVP hydrogels obtained by the two types of reation analysing the gel fraction and the tumescence of the obtained samples. With the hydrogel reticulations with Fenton reaction, all the hydrogels obtained in p H 2.5 present good properties, being that by ionizing radiation only the 15 and 20% of PVP in both p H. Therefore, the comparative study was performed with samples of 15 and 20% of PVP, under tampon phosphate of p H 2.5 by reticulated by gamma radiation, for that presented equivalent properties