Published November 1996 | Version v1
Journal article Metadata-only

Design and application of radiation absorbed dose calculations for 153Sm-EDTMP therapy to painful bone metastases

Creators

  • 1. Shanghai Medical Univ. (China). Zhongshan Hospital

Description

The authors designed a programme to analyse radiation absorbed dose. Samarium-153-ethylenediaminetetra-methylinephosphonic acid (153Sm-EDTMP) was administered to 17 patients as a clinical therapy to palliate painful osseous metastases. SmDOSE programme was compiled with C language, and dosimetry calculation was based on pharmacokinetic studies. The skeletal activity was 1044.14 +- 243.83 MBq·h-1 and the cumulated skeletal activity was 67314.84 +- 16325.14 kBq·h-1. Radiation absorbed dose of red marrow from the therapeutical activity was 213.77 +-55.82 cGy, lower than the nominated maximum red marrow dose (285 cGy). SmDOSE programme is rather effective for dosimetric calculation and be sued to study the dose, efficacy and toxicity of 153Sm-EDTMP

Additional details

Publishing Information

Journal Title
Acta Academiae Medicinae Shanghai
Journal Volume
23
Journal Issue
6
Journal Page Range
p. 464-466.
ISSN
0257-8131
CODEN
SYDXEE

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
28045901
Subject category
S99: GENERAL AND MISCELLANEOUS; S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
Descriptors DEI
BONE MARROW; CARCINOMAS; DOSIMETRY; LABELLED COMPOUNDS; METASTASES; PAIN; PHOSPHONATES; PROGRAMMING; PROGRAMMING LANGUAGES; RADIATION DOSES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RADIOTHERAPY; SAMARIUM 153; SKELETAL DISEASES; SKELETON
Descriptors DEC
ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; EVEN-ODD NUCLEI; HEMATOPOIETIC SYSTEM; INTERMEDIATE MASS NUCLEI; ISOTOPES; KINETICS; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI; SAMARIUM ISOTOPES; SYMPTOMS; THERAPY