Potential pancreatic imaging agents. Tellurium-123m labeled DL-α-amino-γ-(phenyltelluro)butyric acid
Description
This report describes the first successful preparation of a /sup 123m/Te-labeled α-amino acid as a potential pancreatic imaging agent. Tellurium-123m labeled DL-α-amino-γ-(phenyltelluro)butyric acid was prepared by basic hydrolysis of the radiolabeled 5-[β-(phenyltelluro)ethyl]hydantoin. The hydantoin was prepared by the reaction of /sup 123m/Te-labeled phenyltellurol, generated by sodium borohydride reduction of diphenyl ditelluride, with 5-(β-bromoethyl)hydantoin. Tissue distribution studies in rats with the /sup 123m/Te-labeled amino acid for periods varying from 30 min to 24 h demonstrated only marginal pancreatic accumulation of radioactivity. The significant result of these studies is that a general synthetic method has been developed for the preparation of /sup 123m/Te-labeled amino acids
Additional details
Publishing Information
- Journal Title
- J. Med. Chem.
- Journal Volume
- 24
- Journal Issue
- 7
- Series
- J. Med. Chem.
- Journal Page Range
- 794-797
- ISSN
- 0022-2623
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14727799
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMINO ACIDS; CHEMICAL PREPARATION; CONTRAST MEDIA; DISTRIBUTION; IMAGES; ISOMERIC NUCLEI; LABELLED COMPOUNDS; LABELLING; PANCREAS; RADIOCHEMISTRY; RADIONUCLIDE KINETICS; RATS; TELLURIUM 123; TISSUES; USES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHEMISTRY; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; EVEN-ODD NUCLEI; GLANDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; STABLE ISOTOPES; SYNTHESIS; TELLURIUM ISOTOPES; VERTEBRATES