Published December 1998 | Version v1
Journal article Metadata-only

Siderophore Transport in Mycobacteria Analyzed by Moessbauer Spectroscopy: Possible Routes to Novel Antibiotics against These Organisms?

Creators

  • 1. Medizinische Universitaet, Isotopenlabor, Technisch-Naturwissenschaftliche Fakultaet (Germany)
  • 2. Hans-Knoell-Institut fuer Naturstoff-Forschung (HKI) (Germany)
  • 3. Robert Koch Institut (Germany)
  • 4. Medizinische Universitaet, Institut fuer Physik (Germany)

Description

Iron uptake of the 57Fe-siderophores ferricrocin, rhizoferrin and citrate in M. smegmatis was analyzed by in situ Moessbauer spectroscopy. Siderophore dependent uptake and metabolic utilization patterns of 57Fe were found. Rhizoferrin is accumulated in the organism and, therefore, represents a suitable candidate for the synthesis of novel siderophore-antibiotics conjugates

Additional details

Identifiers

DOI
10.1023/A:1011053130791;

Publishing Information

Journal Title
Hyperfine Interactions
Journal Volume
112
Journal Issue
1-4
Journal Page Range
p. 123-128
ISSN
0304-3843
CODEN
HYINDN

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
40058586
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANTIBIOTICS; CITRATES; IRON; IRON 57; MOESSBAUER EFFECT; SYNTHESIS; UPTAKE
Descriptors DEC
ANTI-INFECTIVE AGENTS; CARBOXYLIC ACID SALTS; DRUGS; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPES; METALS; NUCLEI; ORGANIC COMPOUNDS; STABLE ISOTOPES; TRANSITION ELEMENTS

Optional Information

Copyright
Copyright (c) 1998 Kluwer Academic Publishers