Published 1990
| Version v1
Journal article
Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram
- 1. Johns Hopkins Medical Institutions, Baltimore, MD (USA)
Description
Citalopram, a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described. (author)
Additional details
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 41
- Journal Issue
- 6
- Series
- Appl. Radiat. Isot.
- Journal Page Range
- 541-543
- ISSN
- 0883-2889
- CODEN
- ARISE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 21070224
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; LABELLING; LIGANDS; LIQUID COLUMN CHROMATOGRAPHY; METHYL IODIDE; RADIOPHARMACEUTICALS; SEROTONIN
- Descriptors DEC
- AMINES; AUTONOMIC NERVOUS SYSTEM AGENT; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHROMATOGRAPHY; DRUGS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES; SYMPATHOMIMETICS; SYNTHESIS; TRYPTAMINES