Published May 2003
| Version v1
Journal article
A review on the study of bioreductive drugs
Creators
- 1. Fudan Univ., Shanghai (China). Shanghai Inst. of Radiation Medicine
Description
Hypoxia is a feature that exists in most solid tumors. Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species. There are 3 main classes of bio-reductive drugs: the nitro-aromatics, N-oxides and quinones. Recently, bio-reductive drugs were combined with GDEPT for the treatment of cancer, in addition to radiation and the chemotherapeutic agents. Bio-reductive drugs will play a significant role in future cancer therapy
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 21
- Journal Issue
- 2
- Journal Page Range
- p. 83-87
- ISSN
- 1000-3436
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35022634
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; CHEMOTHERAPY; ENZYME INHIBITORS; EVALUATION; HETEROCYCLIC COMPOUNDS; MITOMYCIN; NEOPLASMS; NITRO COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PHARMACOLOGY; QUINONES; RADIOSENSITIZERS; RADIOTHERAPY; REDUCING AGENTS; TOXICITY
- Descriptors DEC
- ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; AROMATICS; DISEASES; DRUGS; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RADIOLOGY; RESPONSE MODIFYING FACTORS; THERAPY