Published 1977 | Version v1
Journal article Metadata-only

The action of piracetam on 14C-glucose metabolism in normal and posthypoxic rat cerebral cortex slices

Creators

  • 1. Polska Akademia Nauk, Warsaw. Centrum Medycyny Doswiadczalnej i Klinicznej

Description

The stimulating effect of piracetam on the respiration and glycolysis was observed in rat brain cortex slices incubated under oxygen atmosphere. After preincubation of the slices under pure nitrogen atmosphere, piracetam influenced also decarboxylation of the C1-glucose carbon, indicating stimulation of the pentose cycle. Any significant effect of piracetam on the lowered by anoxia incorporation of 14C from U-14C-glucose into macromolecular fractions was not observed. The results have supported a protective effect of piracetam against oxygen deficiency, caused mainly by stimulation of metabolic glucose pathways, connected with energy production in CNS. (author)

Additional details

Publishing Information

Journal Title
Pol. J. Pharmacol. Pharm.
Journal Volume
29
Journal Issue
2
Series
Pol. J. Pharmacol. Pharm.
Journal Page Range
111-116
ISSN
0301-0244

INIS

Country of Publication
Poland
Country of Input or Organization
Poland
INIS RN
11565288
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
CARBON 14 COMPOUNDS; CEREBRAL CORTEX; DRUGS; EXPERIMENTAL DATA; GLUCOSE; GLYCOLYSIS; GRAPHS; ISOLATED VALUES; METABOLISM; PENTOSES; RATS; RESPIRATION; UPTAKE
Descriptors DEC
ALDEHYDES; ANIMALS; BODY; BRAIN; CARBOHYDRATES; CARBON COMPOUNDS; CENTRAL NERVOUS SYSTEM; CEREBRUM; CHEMICAL REACTIONS; DATA; DATA FORMS; DECOMPOSITION; HEXOSES; INFORMATION; MAMMALS; MONOSACCHARIDES; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; RODENTS; SACCHARIDES; VERTEBRATES