Published May 2001 | Version v1
Journal article Metadata-only

The preparation and preliminary animal experiment of 153Sm-pingyangmycin

Creators

  • 1. Academia Sinica, Shanghai (China). Shanghai Inst. of Nuclear Research
  • 2. Pectoral Tumor Laboratory of Shanghai Pectoral Hospital, Shanghai (China)

Description

153Sm-Pingyangmycin has been prepared by the reaction of 153SmCl3 and Pingyangmycin. When the labelling condition was 1 mg Pingyangmycin, pH 5 - 6, 30 min reaction time, the labelling yield was greater than 98%. The in vitro stability of 153Sm- Pingyangmycin was good in 72 h. The results of the tissue distribution in Sarcomas-180 mice showed that tumor uptake at 3 h after injection was (1.615 +- 0.219)% ID/g and femur uptake at 6 h was (16.142 +- 3.501)% ID/g. The ratios of tumor/blood and femur/blood at 24 h were 48 and 908 respectively. 153Sm-Pingyangmycin may be used for the treatment of tumor and bone tumor

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
24
Journal Issue
5
Journal Page Range
p. 421-424
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
32044475
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANTINEOPLASTIC DRUGS; BLOOD; CHEMICAL PREPARATION; FEMUR; NEOPLASMS; SAMARIUM 153; SAMARIUM CHLORIDES; SARCOMAS; THERAPY; TISSUE DISTRIBUTION; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CHLORIDES; CHLORINE COMPOUNDS; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; HALIDES; HALOGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOTOPES; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ORGANS; RADIOISOTOPES; RARE EARTH COMPOUNDS; RARE EARTH NUCLEI; SAMARIUM COMPOUNDS; SAMARIUM ISOTOPES; SKELETON; SYNTHESIS