Published August 1989
| Version v1
Journal article
The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water
- 1. UCLA School of Medicine, Los Angeles, CA (USA)
Description
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centers on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques
Additional details
Publishing Information
- Journal Title
- Journal of Cerebral Blood Flow and Metabolism
- Journal Volume
- 9
- Journal Issue
- 4
- Series
- J. Cereb. Blood Flow Metab.
- Journal Page Range
- 461-470
- ISSN
- 0271-678X
- CODEN
- JCBMD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21007209
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD FLOW; BRAIN; CARBON DIOXIDE; EMISSION COMPUTED TOMOGRAPHY; MAN; MEASURING METHODS; OXYGEN 15; TISSUE DISTRIBUTION; WATER
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON COMPOUNDS; CARBON OXIDES; CENTRAL NERVOUS SYSTEM; CHALCOGENIDES; COMPUTERIZED TOMOGRAPHY; DISTRIBUTION; EVEN-ODD NUCLEI; HYDROGEN COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; OXYGEN ISOTOPES; POLAR SOLVENTS; PRIMATES; RADIOISOTOPES; SOLVENTS; TOMOGRAPHY; VERTEBRATES