Toxicity of 144Ce inhaled in a relatively insoluble form by Beagle dogs. XVIII

The long-term biological consequences of inhaling graded activity levels of an insoluble form of 144Ce are being studied in life-span studies of Beagle dogs. One hundred and eleven young adult dogs received single, brief inhalation exposures of 144Ce in fused aluminosilicate particles that resulted in initial lung burdens ranging from 0.0024 to 210 μCi/kg body weight (0.089 to 7800 kBq/kg), and 15 others inhaled nonradioactive fused aluminosilicate particles. At the present time (at least 14 yr after exposure), 102 144Ce-exposed and 14 control dogs have died or been euthanized. Observations are continuing on the remaining 9 144Ce-exposed and 1 control dogs. 3 references, 3 figures, 1 table