Published June 2012
| Version v1
Journal article
Progress on clustered DNA damage in radiation research
- 1. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou (China)
- 2. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China)
- 3. Gansu Academy of Medical Sciences, Lanzhou (China)
- 4. School of Life Sciences, Lanzhou University (China)
Description
Clustered DNA damage which caused by high LET heavy ion radiation can lead to mutation, tumorigenesis and apoptosis. Promoting apoptosis of cancer cells is always the basis of cancer treatment. Clustered DNA damage has been the hot topic in radiobiology. The detect method is diversity, but there is not a detail and complete protocol to analyze clustered DNA damage. In order to provide reference for clustered DNA damage in the radiotherapy study, the clustered DNA damage characteristics, the latest progresses on clustered DNA damage and the detecting methods are reviewed and discussed in detail in this paper. (authors)
Additional details
Publishing Information
- Journal Title
- Nuclear Physics Review
- Journal Volume
- 29
- Journal Issue
- 2
- Journal Page Range
- p. 196-201
- ISSN
- 1007-4627
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 45059234
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- APOPTOSIS; DNA DAMAGES; HEAVY IONS; LET; MUTATIONS; NEOPLASMS; RADIOBIOLOGY; RADIOTHERAPY
- Descriptors DEC
- BIOLOGY; CHARGED PARTICLES; DISEASES; ENERGY TRANSFER; IONS; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY
Optional Information
- Notes
- 1 figs., 2 tabs., 25 refs.