Published December 2005 | Version v1
Journal article Metadata-only

Distribution of lead in the brain tissues from DNTC patients using synchrotron radiation microbeams

Creators

  • 1. International Innovation Center, Kyoto University, Kyoto (Japan)
  • 2. Department of Precision Engineering, Kyoto University, Yoshida Honnmachi, Sakyo-ku, Kyoto (Japan)
  • 3. Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya (Japan)
  • 4. Obu Dementia Care Research and Training Center, Obu (Japan)

Description

Diffuse neurofibrillary tangles with calcification (DNTC) is a form of dementia with certain characteristics. Its pathology is characterized by cerebrum atrophy, calcification on globus pallidus and dentate nucleus and diffuse neurofibrillary tangles without senile plaques. In the present study brain tissues were prepared from patients with patients DNTC, calcified and non-calcified Alzheimer's disease (AD) patients. The brain tissues were examined non-destructively by X-ray fluorescence (XRF) spectroscopy using synchrotron radiation (SR) microbeams for trace metallic elements Ca, Fe, Cu, Zn and Pb. The XRF analysis showed that there were Pb concentrations in the calcified areas in the brain tissues with both DNTC and AD but there was none in those with non-calcified AD

Additional details

Identifiers

DOI
10.1016/j.nimb.2005.07.164;
PII
S0168-583X(05)01301-7;

Publishing Information

Journal Title
Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
Journal Volume
241
Journal Issue
1-4
Journal Page Range
p. 681-684
ISSN
0168-583X
CODEN
NIMBEU

Conference

Title
18. international conference on the application of accelerators in research and industry
Acronym
CAARI 2004
Dates
10-15 Oct 2004
Place
Fort Worth, TX (United States)

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
37072770
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ATROPHY; CEREBRUM; DISEASES; DISTRIBUTION; FLUORESCENCE; LEAD; PATHOLOGY; PATIENTS; SPECTROSCOPY; SYNCHROTRON RADIATION; X RADIATION; X-RAY FLUORESCENCE ANALYSIS
Descriptors DEC
BODY; BRAIN; BREMSSTRAHLUNG; CENTRAL NERVOUS SYSTEM; CHEMICAL ANALYSIS; ELECTROMAGNETIC RADIATION; ELEMENTS; EMISSION; IONIZING RADIATIONS; LUMINESCENCE; METALS; NERVOUS SYSTEM; NONDESTRUCTIVE ANALYSIS; ORGANS; PATHOLOGICAL CHANGES; PHOTON EMISSION; RADIATIONS; X-RAY EMISSION ANALYSIS

Optional Information

Copyright
Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.