Published November 2013 | Version v1
Journal article Metadata-only

A quantitative model of bacterial mismatch repair as applied to studying induced mutagenesis

Creators

  • 1. Joint Institute for Nuclear Research, Dubna (Russian Federation)
  • 2. School of Mathematics and Computer Science, National University of Mongolia, Ulaanbaatar (Mongolia)
  • 3. Mathematics Department, Faculty of Science, Cairo University, Giza (Egypt)

Description

The paper presents a mathematical model of the DNA mismatch repair system in Escherichia coli bacterial cells. The key pathways of this repair mechanism were simulated on the basis of modern experimental data. We have modelled in detail five main pathways of DNA misincorporation removal with different DNA exonucleases. Here we demonstrate an application of the model to problems of radiation-induced mutagenesis.

Availability note (English)

Available from http://link.springer.com/openurl/pdf?id=doi:10.1134/S1547477113060046

Additional details

Identifiers

URL
http://link.springer.com/openurl/pdf?id=doi:10.1134/S1547477113060046;
DOI
10.1134/S1547477113060046;

Publishing Information

Journal Title
Physics of Particles and Nuclei Letters (Print)
Journal Volume
10
Journal Issue
6
Journal Page Range
p. 587-596
ISSN
1547-4771

INIS

Country of Publication
Russian Federation
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
52085598
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
DNA MISMATCH; DNA REPAIR; ESCHERICHIA COLI; MATHEMATICAL MODELS; MUTAGENESIS; SIMULATION
Descriptors DEC
BACTERIA; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; MICROORGANISMS; REPAIR

Optional Information

Copyright
Copyright (c) 2013 Pleiades Publishing, Ltd.