Comparative characteristics of pharmacological properties of novocaine and trimecaine in different periods after thermal, mechanical, radiation and combined injury

The study of effectiveness of trimecaine hydrochloride as compared with novocaine after mechanic in ury, thermal injuru, radiation effect and the combination of these factors included the determination of sensitivity of animals to preparations investigated according to toxicity tests and anesthetic activity (aiesthesia duration and depth) in dfferent periods after injury. Breedless male mice and rabbits are used for eXperiments. Sensitivity of mice to novocaine and trimecaine in the toxicity test turned out to be close to xilocaine (lidocaine) 1.4 times higher; this regularity is preserved against the back-groUrd of thermal injury, radiation in ury and the combination of these two factors. The anesthetic effect of novacaine and trimecaine in the case of infiltration anesthesia in depth and duration is retained through all periods of investigation (after 1, 3, 7, and 30 days) after mechanic injury and combined radiation-mechanic imjury. Trimecaine produced more pronounced anesthetic effect in duration and depth in intact animals and animals with combined radiation injury (2). Trimecaine along with novocaine is recommended as an optional preparation for local anesthesia in cases of combined radiation in ury