The clinical value of dipyridamole 99mTc-MIBI myocardial perfusion tomography for diagnosing coronary heart disease and assessing therapeutic effect

In this study, the results of EKG and 99mTc labelled MIBI radionuclide myocardial tomography after giving dipyridamole 99mTc-MIBI SPECT) intravenously in 70 cases of coronary artery disease were compared to the findings by coronary angiography. It was found that the sensitivity and specificity of 99mTc-MIBI SPECT for coronary artery stenosis of more than 50% were 88% and 93%, respectively, vs. 52% and 77%, respectively, found by EKG. The differences were both statistically significant. The sensitivity of 99mTc-MIBI SPECT in detecting lesion of LAD, LCX and RA was 82%, 84% and 83%, respectively. Its prospective sensitivity for detection of single vessel disease was 82%. In addition, the results of 99mTc-MIBI SPECT performed pre-PTCA compared to those of post-PTCA in 17 cases suggest that 99mTc-MIBI SPECT has high sensitivity and specificity in the diagnosis of coronary artery disease. It is also a good method in screening the candidates for PTCA