Study on bone resorption behavior of osteoclast under drug effect using 41Ca tracing
Creators
- 1. China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China)
- 2. CNNC Third Qinshan Nuclear Power Co. Ltd., Haiyan 314300 (China)
- 3. College of Physics Science and Technology, Guangxi University, Nanning 530004 (China)
- 4. College of Physics and Technology, Guangxi Normal University, Guilin 541004 (China)
- 5. Institute of Radiation Medicine, Fudan University, Shanghai 200032 (China)
- 6. China National Nuclear Corporation, Beijing 100822 (China)
- 7. Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035 (China)
Description
The mechanisms governing calcium fluxes during bone remodeling processes in Osteoporosis (OP) patients are poorly known. Understanding the changes of Osteoclasts (OC) during this dynamic transition is important to prevent and cure OP. The exploration of long-lived 41Ca (T1/2 = 1.04 × 105 years) tracer combined with AMS measurements leads to the possibility of monitoring the bone resorption behavior of OC in OP patients. In this work, the behavior of OC with the administration of Strontium Ranelate (SR), a drug for OP, was studied by using 41Ca labeled hydroxyapatite (HAP) to simulate the bone. AMS on the HI-13 tandem accelerator at CIAE was used to determine trace amounts of 41Ca. The results show that the technique of 41Ca tracing with AMS can be used to quantitatively monitor the behavior of OC in bone resorption under the effects of drugs. Experimental details and preliminary results will be presented.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.nimb.2012.08.051Additional details
Identifiers
- DOI
- 10.1016/j.nimb.2012.08.051;
- PII
- S0168-583X(12)00577-0;
Publishing Information
- Journal Title
- Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
- Journal Volume
- 294
- Journal Page Range
- p. 671-674
- ISSN
- 0168-583X
- CODEN
- NIMBEU
Conference
- Title
- 12. international conference on accelerator mass spectrometry
- Dates
- 20-25 Mar 2011
- Place
- Wellington (New Zealand)
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 44085069
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- APATITES; CALCIUM; CALCIUM 41; MASS SPECTROSCOPY; OSTEOPOROSIS; SKELETON; STRONTIUM; TANDEM ELECTROSTATIC ACCELERATORS; TRACE AMOUNTS
- Descriptors DEC
- ACCELERATORS; ALKALINE EARTH ISOTOPES; ALKALINE EARTH METALS; BETA DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ELECTROSTATIC ACCELERATORS; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPES; METALS; MINERALS; NUCLEI; ORGANS; PHOSPHATE MINERALS; RADIOISOTOPES; SKELETAL DISEASES; SPECTROSCOPY; YEARS LIVING RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.