Published August 1983 | Version v1
Journal article Metadata-only

Behaviour of lysosomal enzymes in the small intestine after multiple daily fractionation

Creators

  • 1. Florence Univ. (Italy). Ist. di Radiologia

Description

Modifications in the activities of some lysosomal enzymes were studied in the small intestine after irradiation on the abdomen by multiple daily fractionation of 3 Gy per fraction every 12 hours. Total doses of 6 and 12 Gy were studied. With lower dose variations were slight. The modifications of acid phosphatase an cathepsin D appeared very low, wheras β-glucuronidase increased until 72 hours after the last fraction and then returned to control values. With respect to 8 Gy single dose the injury appeared comparatively similar. (orig.)

Abstract (German)

Nach taeglich mehrfach fraktionierter Bestrahlung des Abdomens mit 3 Gy/12 Stunden wurden die Veraenderungen der Aktivitaet einiger lysosomaler Enzyme im Duenndarm untersucht. Die Gesamtdosis betrug 6 und 12 Gy. Bei geringerer Dosis waren nur leichte Schwankungen zu verzeichnen. Die Veraenderungen waren bei der sauren Phosphatase und bei Kathepsin D sehr gering; der β-Glukuronidase-Spiegel dagegen stieg bis zu 72 Stunden nach der letzten Fraktion an und sank dann wieder auf die Kontrollwerte ab. Durch eine einmalige Dosis von 8 Gy wurden aehnliche Schaeden wie bei fraktionierter Bestrahlung hervorgerufen. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
159
Journal Issue
8
Series
CODEN: STRAA.;Strahlentherapie.
Journal Page Range
508-512
ISSN
0039-2073

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
15005823
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CATALYSIS; EARLY RADIATION EFFECTS; ENZYMES; FRACTIONATED IRRADIATION; GAMMA RADIATION; LYSOSOMES; MEV RANGE 01-10; RADIATION DOSES; RATS; SMALL INTESTINE; TIME DEPENDENCE
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CELL CONSTITUENTS; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ENERGY RANGE; GASTROINTESTINAL TRACT; INTESTINES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEV RANGE; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES