Cholinergic and VIPergic effects on thyroid hormone secretion in the mouse
Creators
Description
The thyroid gland is known to harbor cholinergic and VIPergic nerves. In the present study, the influences of cholinergic stimulation by carbachol, cholinergic blockade by methylatropine and stimulation with various VIP sequences on basal, TSH-induced and VIP-induced thyroid hormone secretion were investigated in vivo in mice. The mice were pretreated with 125I and thyroxine; the subsequent release of 125I is an estimation of thyroid hormone secretion. It was found that basal radioiodine secretion was inhibited by both carbachol and methylatropine. Furthermore, TSH-induced radioiodine secretion was inhibited already by a low dose of carbachol. Moreover, a high dose of carbachol could inhibit VIP-induced radioiodine secretion. Methylatropine did not influence TSH- or VIP-stimulated radioiodine secretion, but counteracted the inhibitory action of carbachol on TSH- and VIP-induced radioiodine release. In addition, contrary to VIP, six various synthesized VIP fragments had no effect on basal or stimulated radioiodine release. It is concluded that basal thyroid hormone secretion is inhibited by both cholinergic activation and blockade. Furthermore, TSH-induced thyroid hormone secretion is more sensitive to inhibition with cholinergic stimulation than is VIP-induced thyroid hormone secretion. In addition, the VIP stimulation of thyroid hormone secretion seems to require the full VIP sequence
Additional details
Publishing Information
- Journal Title
- Peptides (Fayetteville, N.Y.)
- Journal Issue
- no.4
- Series
- Peptides (Fayetteville, N.Y.).
- ISSN
- 0196-9781
- CODEN
- PPTDD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17068328
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL EFFECTS; CHICKENS; IODINE 125; MICE; NERVES; PARASYMPATHOMIMETICS; SECRETION; SHEEP; THYROID; THYROXINE; TRACER TECHNIQUES; TSH
- Descriptors DEC
- AMINO ACIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BIRDS; BODY; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DOMESTIC ANIMALS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; FOWL; GLANDS; HORMONES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; RADIOISOTOPES; RODENTS; RUMINANTS; THYROID HORMONES; VERTEBRATES