Practical aspects of the preparation of 99mTc-labeled radiopharmaceuticals using cold kit

This paper describes notes for preparation of radiopharmaceuticals (RP) based on the legal standard, package inserts and academic papers. The nuclide 99mTc is the most popular one among RP and labels compounds by ligand-replacement or complex-formation. Radiochemical purity of RP, particularly important for the diagnostic specificity, is practically examined by chromatography (paper, thin-layer, high-performance liquid, electrophoresis, etc). The chromatographic radioactivity is detected by autoradiography, NaI(Tl) scanner or cut-and-count procedure. The sterility and milking interval are important for preparation. Finally, 15 RP specifications are summarized: 99mTc-labeled ECD, HMPAO, MIBI, tetrofosmin, HSA, pyrophosphate, MDP, HMDP, MAA, Sn colloid, phytate, MAG3, DTPA and DMSA (2 preparations). (N.I.)