The regularities of precise excision of Tn10 transposon in E. coli cells after irradiation with accelerated heavy ions with different LET

The induction of structural mutations in bacteria Escherichia coli by ionizing radiation with different physical characteristics is considered. The regularities of precise transposon Tn10 excision after 4He and 12C heavy ions with different linear energy transfer (LET) are studied. The dose-response relationships for survival cells and transposon excision are obtained. It is shown that the frequency of precise transposon Tn10 excision as a function of the dose of heavy ions is described by a power function. The dependences of relative biological effectiveness (RBE) on LET for survival cells and transposon excision are studied