Published 1985 | Version v1
Report Open

Positron-emitting radioligands for imaging neuroleptic receptors

Creators

Description

A series of 18F-labeled butyrophenones (benperidol, haloperidol, spiroperidol and N-methylspiroperidol) were evaluated in baboons and rats with respect to potential utility as radioligands for studying neuroleptic receptors in the living human brain by positron emission tomography. These compounds were administered to baboons, and the radioactivity distributions to the striatum, and to the cerebellum were determined by PET at times up to 8 hours after isotope injection. 4 refs. (DT)

Availability note (English)

MF available from INIS under the Report Number; Available from NTIS, PC A02; 3 as DE85017516.

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Additional details

Publishing Information

Imprint Pagination
2 p.
Report number
BNL--36886

Conference

Title
12. international symposium on cerebral blood flow and metabolism.
Dates
16-20 Jun 1985.
Place
Lund (Sweden).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17022478
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
APES; CEREBELLUM; CEREBRUM; DISTRIBUTION; FLUORINE 18; METABOLISM; POSITRON COMPUTED TOMOGRAPHY; RATS; TIME DEPENDENCE; TISSUES; TRACER TECHNIQUES; TRANQUILIZERS
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANS; PRIMATES; PSYCHOTROPIC DRUGS; RADIOISOTOPES; RODENTS; TOMOGRAPHY; VERTEBRATES

Optional Information

Secondary number(s)
CONF-8506187--1.