Age-related effects of gamma-radiation on testosterone-binding globulin characteristic an testosterone content in blood of rats

Prolonged external low-intensity (3.03 cGy/day) gamma-irradiation of Wismar male rats at different doses (25-100 cGy), in varied periods of time, resulted in marked transitory increases in blood serum testosterone content, simultaneously accompanied by dramatic falls in specific testosterone-blinding globulin concentration, coupled with regulatory-mediated changes of its molecular properties (cooperative and conformational reconstructions). The significance of the phenomena (as adaptation blood hormone-transport system reactions) for correction and compensation of radiation-induced disbalance is discussed (authors)