Published October 1, 2019 | Version v1
Journal article Metadata-only

Effect of perithyroidal lignocaine infusion (PLI) to pain experienced during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules

Creators

  • 1. The University of Hong Kong, Department of Surgery, Queen Mary Hospital (China)
  • 2. The University of Hong Kong, Department of Medicine (China)
  • 3. The University of Hong Kong, Department of Radiology (China)

Description

Objective

To assess whether perithyroidal lignocaine infusion (PLI) could provide additional analgesia in high-intensity focused ultrasound (HIFU) treatment of benign thyroid nodules for patients already receiving their usual intravenous doses of Pethidine and Diazemuls.

Methods

Two hundred and five patients who underwent HIFU ablation for a benign thyroid nodule were analyzed. Among them, 104 (50.7%) patients received PLI in addition to their boluses of Pethidine and Diazemuls before treatment (group I), while the rest (n = 101, 49.3%) received intravenous Pethidine and Diazemuls only (group II). After treatment, patients were asked to rate their overall pain experience on a visual analogue scale (VAS) (0–100) (0, no pain; 100, worse possible pain) during treatment. Binary logistic regression was performed to evaluate significant determinants for treatment pain including demographics, doses of medications, and treatment parameters.

Results

VAS was significantly lower in group I (51.30 vs. 63.79, p = 0.002). In the multivariate analysis, older age at treatment (OR = 1.036, 95%CI = 1.008–1.065, p = 0.011), lower BMI (OR = 1.202, 95%CI = 1.083–1.334, p = 0.001), higher Diazemuls dose (OR = 1.066, 95%CI = 1.018–1.114, p = 0.006), and use of PLI (OR = 2.096, 95%CI = 1.121–3.922, p = 0.020) were independent determinants of less treatment pain.

Conclusions

PLI can provide additional analgesia in patients already receiving their usual intravenous doses of Pethidine and Diazemuls during HIFU ablation of benign thyroid nodules. Older age, lower body mass index, and greater Diazemuls (i.e., a sedative) dose are significantly associated with less treatment pain.

Key Points

• PLI provided an additional analgesic effect in HIFU ablation of thyroid nodules.

• Older age and lower BMI were significantly associated with less pain.

• Higher doses of Diazemuls lessened pain during HIFU ablation.

Additional details

Identifiers

DOI
10.1007/s00330-019-06160-5;

Publishing Information

Journal Title
European Radiology
Journal Volume
29
Journal Issue
10
Journal Page Range
p. 5280-5287
ISSN
0938-7994
CODEN
EURAE3

INIS

Country of Publication
Germany
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54094613
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
GOITER; HYPNOTICS AND SEDATIVES; MULTIVARIATE ANALYSIS; PATIENTS; PETHIDINE; THYROID; ULTRASONOGRAPHY
Descriptors DEC
AMINES; ANALGESICS; AROMATICS; AZINES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; MATHEMATICS; MONOCARBOXYLIC ACIDS; NARCOTICS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PIPERIDINES; PYRIDINES; STATISTICS

Optional Information

Copyright
Copyright (c) 2019 European Society of Radiology