The application of retinoic acids in the 131I treatment with differentiated thyroid carcinoma

Differentiated thyroid carcinoma (DTC) can occur dedifferentiation in the progress of the process, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. It became one of the most thorny problem for the treatement of DTC now. Retinoic acids, the biologicallyactive metabolite of vitamin A, is of central importance for growth, differentiation, apoptosis and others vital movement of cells. It is demonstrated by studies that retinoic acids-induced redifferentiaon could raise the competence of tumor ingest 131I, accordingly raise effect of the DTC treatment. (authors)