Published August 1, 1990
| Version v1
Journal article
Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of therapeutic radon exposure
- 1. Tel-Aviv Univ. (Israel)
Description
A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by therapeutic low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18,del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia
Additional details
Publishing Information
- Journal Title
- Cancer Genetics and Cytogenetics
- Journal Volume
- 48
- Journal Issue
- 1
- Series
- Cancer Genet. Cytogenet.
- Journal Page Range
- 125-130
- ISSN
- 0165-4608
- CODEN
- CGCYD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22008502
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHROMOSOMAL ABERRATIONS; DELAYED RADIATION EFFECTS; LOW DOSE IRRADIATION; MUTAGENESIS; MYELOID LEUKEMIA; RADIATION EFFECTS; RADIATION HAZARDS; RADIOTHERAPY; RADON; SIDE EFFECTS; SPONDYLITIS
- Descriptors DEC
- BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; ELEMENTS; HAZARDS; HEALTH HAZARDS; HEMIC DISEASES; IRRADIATION; LEUKEMIA; MEDICINE; MUTATIONS; NEOPLASMS; NONMETALS; RARE GASES; SKELETAL DISEASES; THERAPY