Published January 1985 | Version v1
Journal article Metadata-only

Radiation-induced binding of 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl to thymidine in oxygen-free aqueous solutions

Creators

  • 1. CEA Centre d'Etudes Nucleaires de Grenoble, 38 (France). Dept. de Recherche Fondamentale
  • 2. CEA Centre d'Etudes Nucleaires de Grenoble, 38 (France)

Description

Steady-state γ-radiolysis of deaerated aqueous solutions of thymidine has been carried out in the presence of 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl (TAN), a well known radiosensitizing agent. The eight main radiation-induced TAN addition products to thymidine have been isolated and characterized by sup(1)H and sup(13)C nmr, cd, and fast-atom bombardment mass spectrometry measurements

Additional details

Additional titles

Subtitle (English)
Isolation and characterization of the adducts

Publishing Information

Journal Title
Can. J. Chem.
Journal Volume
63
Journal Issue
1
Series
Can. J. Chem.
Journal Page Range
6-14
ISSN
0008-4042
CODEN
CJCHA

INIS

Country of Publication
Canada
Country of Input or Organization
Canada
INIS RN
17035103
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AQUEOUS SOLUTIONS; G VALUE; GAMMA RADIATION; MASS SPECTRA; NUCLEAR MAGNETIC RESONANCE; RADIOLYSIS; RADIOSENSITIZERS; THYMIDINE; TRIACETONEAMINE-N-OXYL
Descriptors DEC
AMINES; AZINES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DECOMPOSITION; DISPERSIONS; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HOMOGENEOUS MIXTURES; IONIZING RADIATIONS; KETONES; MAGNETIC RESONANCE; MIXTURES; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PIPERIDINES; PYRIDINES; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RESONANCE; RESPONSE MODIFYING FACTORS; RIBOSIDES; SOLUTIONS; SPECTRA