Published 1986 | Version v1
Journal article Metadata-only

Application of hyperglycemia induction in combination with radiotherapy for rectal cancer treatment

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Moscow. Onkologicheskij Nauchnyj Tsentr

Description

A treatment modality employing radiotherapy wih subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally - extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patientswo received who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side-effects developed. The results are encouraging and seem to open up new vistas of clinical research

Additional details

Additional titles

Original title (Russian)
Ispol'zovanie iskusstvennoj giperglikemii pri luchevom lechenii bol'nykh rakom pryamoj kishki

Publishing Information

Journal Title
Vopr. Onkol.
Journal Volume
32
Journal Issue
10
Journal Series
Vopr. Onkol.
Journal Page Range
40-46
ISSN
0507-3758
CODEN
VOONA

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
18045683
Subject category
RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Quality check status
Yes
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; EHRLICH ASCITES TUMOR; HYPERGLYCEMIA; INTRAMUSCULAR INJECTION; INTRAPERITONEAL INJECTION; LOCAL IRRADIATION; MICE; RECTUM; SIDE EFFECTS; SURVIVAL CURVES; TRANSPLANTS; TUMOR CELLS; X RADIATION;
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; EXPERIMENTAL NEOPLASMS; GASTROINTESTINAL TRACT; INJECTION; INTAKE; INTESTINES; IONIZING RADIATIONS; IRRADIATION; LARGE INTESTINE; MAMMALS; NEOPLASMS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES;