Study of radioprotective effect of crataegus on mouse by intraperitoneally injection

Objective: To explore the radioprotective effect of Crataegus on Mouse by intraperitoneally injection. Methods: 60 mice were randomly divided into five groups: normal control, irradiation, irradiation + high dosage, irradiation + middle dosage, irradiation + low dosage. The latter three groups were injected intraperitoneally with Crataegus extract 1 hour before they were irradiated by 60Co γ. The others were given physiological brine. The body weight and Peripheral blood routine were measured at 4h before irradiation and 6,12 days after irradiation. DNA content and quantity of nucleocyte in bone marrow were observed at 12 days after irradiation. Results: (1)After injection 8 mice died of infecton and hemorrhage in high dose group, and all the others survived. (2)In contrast with the irradiation group, the extract of Crataegus in three different concentrations has the effect of promoting the recovery of WBC, PLT counts in peripheral blood of mice with radiation injury mice. Conclusion: The extract of Crataegus can promote recovery of hematological function and protect the bone marrow DNA and nucleocyte of radiation injury mice. (authors)